Eat Fat, Get Thin by Dr Mark Hyman
Author:Dr Mark Hyman [Dr Mark Hyman]
Language: eng
Format: epub
Publisher: Hodder and Stoughton
Published: 2016-02-01T16:00:00+00:00
If you have abnormal values on these tests you will tend to do better on a higher-fat, lower-carb diet. If they are totally normal, you may be able to include more healthy starchy veggies, whole grains, and beans once you transition to the Pegan Diet. You can monitor those numbers and see how different approaches to eating affect you.
TESTING YOUR GENES
Many of us would like to blame our parents or our genes for our weight or health problems. It would be easy to say that you have the genes for obesity or diabetes, that your parents and grandparents were overweight or had diabetes or heart disease, so you do, too. But the world of genetics is much more complicated than that.
Each of us has about 20,000 genes. Approximately 99 percent of those genes are identical to every other human on the planet; the other 1 percent is what makes us unique. You have about 112 million variations on those genes, called single nucleotide polymorphisms (SNPs for short), which influence every function of your body, including your need for vitamins, your ability to detoxify, and your tendency toward inflammation, heart disease, cancer, and much more. These SNPs also influence your weight and metabolism and your ability to process or manage fat in your diet.
Every day we are learning more about these SNPs and how they influence our health. We know enough today to start using genetic tests to help personalize our approach to health and nutrition. Soon we will be able to take a swab of our cheek, send it in, and for a few hundred dollars know our whole genome and match our food, supplement, and exercise needs to our own genes, optimizing function and metabolism. Up to 40 to 50 percent of the variance in body weight among people may be due to genetic factors, which is why different people respond differently to different diets.12
For some of my patients, I order genetic testing to help guide me in personalizing recommendations. There are some genes that help me tailor my approach for each person. These specific genes are linked to obesity and the tendency to gain weight, and how cholesterol profiles may respond to a high-or low-fat diet,13 metabolic rate, absorption of dietary fat, mobilization of fat from cells, and the ability to burn fat for energy. There are genes that regulate dopamine receptors in the brain, which control your likelihood of craving carbs and sugar, and genes that can predict levels of insulin resistance, inflammation, cholesterol metabolism, and even how your body responds to different types of exercise.
I’ve listed below some of the genes I test for (and that you can easily test for with a home test kit—see www.eatfatgetthin.com for details):
FABP2: influences your absorption and metabolism of fat
PPARG: affects your insulin function, fat burning, and cholesterol levels
ADRB2: affects how your body mobilizes fat from fat cells for energy
ADRB3: affects how your body breaks down fat
APOA5: regulates your triglycerides
APOA2: affects the risk of obesity, cholesterol metabolism, risk of heart
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